姓名：刘雅妮，博士

职称：讲师

学习经历：

2012.09-2015.07河北医科大学基础医学院药理学专业，博士，导师：张海林

2009.09-2012.07河北医科大学基础医学院药理学专业，硕士，导师：张海林

2005.09-2009.07河北医科大学ylzzcom永利总站检测网址药学专业，本科

工作经历：

2021.11-至今ylzzcom永利总站线路通道医学部ylzzcom永利总站检测网址药理系，讲师

2016.12-2021.10ylzzcom永利总站线路通道医学部，博士后，合作导师：王克威

2015.08-2016.11军事医学科学院，科研助理

个人简介：

刘雅妮，博士，药理系讲师。主要研究领域为靶向Nav1.7通道抑制剂的镇痛作用评价及机制研究，钙激活氯通道ANO1作为外周疼痛的靶标确证及机制研究。在APSB、APS、FASEBJ等杂志发表SCI文章十余篇，主持国家自然科学基金和山东省自然科学基金各一项。

研究方向：

1.靶向Nav1.7通道抑制剂的镇痛作用评价及机制研究

2.钙激活氯通道ANO1作为外周疼痛的靶标确证及机制研究

代表性论著（近5年，不超过10篇）

1Yufen Yan, Xiaoyan Ding, Chunhua Han, Jianjun Gao, Zongtao Liu,Yani Liu∗, KeWei Wang*. Involvement of TMEM16A/ANO1 upregulation in the oncogenesis of colorectal cancer.Biochim Biophys Acta Mol Basis Dis. 2022 Feb 26;166370. doi: 10.1016/j.bbadis.2022.166370.

2Dengqi Xue#,Yani Liu#∗, Yilin Zheng, Heling Niu, Liying Dong, Xiangshuo Ouyang, Siyu Song, Denggao Zhang, Qianwei Ge, Kewei Wang, Liming Shao∗.Design and synthesis of novel α-aminoamides derivatives as Nav1.7 inhibitors for antinociception.Chinese Chemical Letters. 2022 Mar; 33(3):1643-1646

3Pan Yang, Qilong Cao,Yani Liu∗, KeWei Wang∗, Wei Zhu∗. Small-molecule-driven direct reprogramming of Müller cells into bipolar-like cells.Cell Proliferation. 2022 Feb;55(2):e13184.

4Heling Niu#,Yani Liu#*, Dengqi Xue#, Liying Dong, Huijie Liu, Jing Wang, Yilin Zheng, Anruo Zou, Liming Shao* and KeWei Wang*. Inhibition of Nav1.7 channel by a novel blocker QLS-81 for alleviation of neuropathic pain.Acta Pharma Sinica. 2021 Aug;42(8):1235-1247.

5Yani Liu*, Zongtao Liu, KeWei Wang*. The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?Acta Pharmaceutica Sinica B. 2021 Jun;11(6):1412-1433.

6Jing Wang#,Yani Liu#, Fang Hu, Jiuyong Yang, Xiaoyu Guo, Xingming Hou, Chuanxia Ju* and KeWei Wang*. Activation of Neuronal Voltage-Gated Potassium Kv7/KCNQ/M-Current by a Novel Channel Opener SCR2682 for Alleviation of Chronic Pain.J Pharmacol Exp Ther. 2021 Apr; 377(1):20-28.

7Yani Liu, Xiling Bian, KeWei Wang*. Pharmacological Activation of Neuronal Voltage-Gated Kv7/KCNQ/M-Channels for Potential Therapy of Epilepsy and Pain.Hankbook of Experimental Pharmacology. 2021;267:231-251. doi: 10.1007/164_2021_458.

8Yani Liu, Huiran Zhang, Hongchao Men, Yuwei Du, ZiQianXiao, Fan Zhang, DongyangHuang, Xiaona Du, Nikita Gamper, Hailin Zhang*. Volume-regulated Cl-current: contributions of distinct Cl-channel and localized Ca2+ signals.American Journal of Physiology-Cell Physiology. 2019 Sep 1;317(3):C466-C480.

9Fan Zhang#,Yani Liu#, Feng Tang, Bo Liang, Huanming Chen, Hailin Zhang, KeWei Wang*. Electrophysiological and pharmacological characterization of a novel and potent neuronal Kv7 channel opener SCR2682 for anti-epilepsy.FASEB Journal. 2019 Aug;33(8):9154-9166.

主要科研项目（近5年，不超过5项）

1国家自然科学基金青年项目：2022.01-2024.01，钙激活氯通道ANO1作为潜在治疗骨转移癌痛新靶标的确证研究，30万元，主持。

2山东省自然科学基金青年项目：2021.01-2023.12，钙激活氯通道ANO1作为新型外周镇痛靶标的确认及机制研究，15万元，主持。

3青岛市博士后应用基础项目研究：2018.01-2019.09，塞来昔布及其同系物抑制钙激活氯通道ANO1的新作用机制研究，5万元，主持。

联系方式：

电话：17860716292

邮箱：liuyani@qdu.edu.cn